Radiation Protocols
Cancer clinical trials are research studies for developing better ways of detecting, treating, and eventually preventing cancer. By taking part in a clinical trial, you are among the first to receive new research treatments before they are widely available. Your participation in a clinical trial will influence the future direction of cancer care.
If you are interested in participating in a clinical trial, consult with your physician. Please note: clinical trials are not risk free. Patients must explore the options that are best for their individuals needs with the help of their physician.
Brain/CNS
COG-ACNS0332: Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients
Physician Summary:
Age 3 - 21 (inclusive); Newly Dx: RT+ Vincristine +/- Carboplatin f/b Maint +/- Continuous Isotretinoin
N0577: Phase III Intergroup Study of Radiotherapy versus Temozolomide alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma
Physician Summary:
> Age 18; Staging: Co-deleted 1p/19q Anaplastic Glioma; Treatment: RT vs Temozolomide alone vs RT with concomitant & Adjuvant Temozolomide.
Breast
NSABP B-43: A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy
Physician Summary:
≥ age 18, Central HER2 Testing: RT +/- Trastuzumab
(Available at Saint Mary's Health Care, Spectrum Health and Bronson Battle Creek) RTOG 1014: A Phase II Study of Repeat Breast Preserving Surgery and 3D-Conformal Partial Breast Re-Irradiation (PBrI) for Local Recurrence of Breast Carcinoma
Physician Summary:
> Age 18; Staging: Locally Recurrent Breast Carcinmoa. Tx: Lumpectomy f/b 3D CRT
B-39: A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer
Physician Summary:
< Age 50 if Stage 0-II; > Age 50 for Stage I & II if Node+ and/or ER-/PR- TX: Conventional Whole Breast Irradiation (WBI) vs. Partial Breast Irradiation (PBI)
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Cancer Control
NSABP B-43: A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy
Physician Summary:
≥ age 18, Central HER2 Testing: RT +/- Trastuzumab
NCCTG N09C6: Randomized Double-Blind Study of Doxepin Rinse versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy with or without Chemotherapy. (Not available at Mercy Health Partners or Battle Creek Health System)
Physician Summary:
> Age 18; Painful Mucositis; Must be receiving Radiotherapy w/ 1/3 of oral cavity included in the radiation therapy fields. Treatment: Doxepin/Placebo
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Gastrointestinal
(Saint Mary's Only) RTOG 0436: A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients With Esophageal Cancer Who Are Treated Without Surgery
Physician Summary:
> Age 18; T1N1M0; T2-4, Any N, M0; Any T, and N, M1a. Treatment: Concurrent Radiation with Paclitaxel and Cisplatin, w/ or w/o Cetuximab
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Genitourinary
(Open at Spectrum Health, Saint Mary's Health Care and Bronson Battle Creek) RTOG 0815 - A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer
Physician Summary:
> Age 18; Staging: T2b-T2c (intermediate risk); Treatment: Dose Escalated RT Alone vs. Dose Escalated RT Combined w/ Short Term Androgen Blockade
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Head and Neck
(Available at Saint Mary's Health Care and Bronson Battle Creek) RTOG 1016: Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharnyx Cancer
Physician Summary:
> Age 18; Staging: T1-2, N2a-3, or T3-4 any N; Must be P16 Positive. Treatment: Cisplatin or Cetuximab w/ Concurrent RT
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Lung
(Available at Saint Mary's & Spectrum Health Only) RTOG 0813 - Seamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) for Early Stage, Centrally Located Non-Small Cell Lung Cancer (NSCLC) in Medically Inoperable Patients
Physician Summary:
> Age 18; NSCLC Stage T1-2, N0, M0; Treatment: SBRT (Stereotactic Lung Radiotherapy)
RTOG 0937-Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer (ED-SCLC). (Available at Spectrum Health and Saint Mary's Health Care Only)
Physician Summary:
> Age 18; Stage IV. Treatment: Prophylactic RT following SOC Chemotherapy
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Melanoma
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Sarcoma
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Unknown Primary
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis