Recently Activated Protocols
Cancer clinical trials are research studies for developing better ways of detecting, treating, and eventually preventing cancer. By taking part in a clinical trial, you are among the first to receive new research treatments before they are widely available. Your participation in a clinical trial will influence the future direction of cancer care.
If you are interested in participating in a clinical trial, consult with your physician. Please note: clinical trials are not risk free. Patients must explore the options that are best for their individuals needs with the help of their physician.
Breast
CALGB 70806 - Vitamin D and Breast Cancer Biomarkers (limited to Saint Mary's Health Care only)
Physician Summary:
< Age 55; FSH < 20; Staging: Vitamin D Levels; Treatment: Vitamin D /Placebo
NSABP/NCIC CTC MA.32.F: Biobehavioral Mechanisms of Fatigue in Patients Treated on NCIC CTG MA.32: A Phase III Randomized Trial of Metformin Versus Placebo on Recurrence and Survival in Early Stage Breast Cancer
Physician Summary:
Companion study to CTSU MA.32. Bio-Specimen Collection and Patient Questionnaires.
NSABP B-47 - A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer
Physician Summary:
>Age 18; Resected Node(+) or High-Risk Node(-) HER2-Low (1+ to 2+ IHC). Treatment: Chemo (Physician’s choice: TC or AC f/b WP) Alone vs Chemo +Trastuzumab
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Cancer Control
CALGB 70806 - Vitamin D and Breast Cancer Biomarkers (limited to Saint Mary's Health Care only)
Physician Summary:
< Age 55; FSH < 20; Staging: Vitamin D Levels; Treatment: Vitamin D /Placebo
NSABP/NCIC CTC MA.32.F: Biobehavioral Mechanisms of Fatigue in Patients Treated on NCIC CTG MA.32: A Phase III Randomized Trial of Metformin Versus Placebo on Recurrence and Survival in Early Stage Breast Cancer
Physician Summary:
Companion study to CTSU MA.32. Bio-Specimen Collection and Patient Questionnaires.
URCC 10055: Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy at Pre-Treatment, Post-Treatment, and at Six Month Follow-Up
Physician Summary:
Invasive Breast Cancer Stage I-IIIC or High-Grade Lymphoma; Chemo Naïve. Patient to complete three Questionnaires.
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Gastrointestinal
MCCRC I4T-MC-JVBT: A Randomized, Placebo-Controlled, Double-Blind Phase 2 Study of mFOLFOX6 Chemotherapy Plus Ramucirumab Drug Product (IMC-1121B) versus mFOLFOX6 Plus Placebo for Advanced Adenocarcinoma of the Esophagus, Gastroesophageal Junction, or Stomach
Physician Summary:
≥ Age 18; Advanced Adenocarcinoma of the Esophagus, GE Junction or Stomach. Treatment: mFOLFOX6 +/- Ramucirumab
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Genitourinary
CALGB 90601 - A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, and Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients with Advanced Transitional Cell Carcinoma
Physician Summary:
> Age 18; Staging: Unresectable Locally Advanced or Metastatic. Treatment: Gemcitabine + Cisplatin + Bevacizumab/Placebo x6 Cycles f/b Maintenance Bevacizumab/Placebo
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Head and Neck
(Available at Saint Mary's Health Care and Bronson Battle Creek) RTOG 1016: Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharnyx Cancer
Physician Summary:
> Age 18; Staging: T1-2, N2a-3, or T3-4 any N; Must be P16 Positive. Treatment: Cisplatin or Cetuximab w/ Concurrent RT
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Lung
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Melanoma
This study is temp closed. E1609: Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon α-2b for Resected High-risk Melanoma
Physician Summary:
> Age 18; Stage IIIB-IV. Treatment: Ipilimumab vs Interferon Alpha. All physicians must complete study specific training prior to patient enrollment
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Sarcoma
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis
Unknown Primary
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis (Spectrum Health Only)
Physician Summary:
> Age 18; Stage IV - Multisite. Treatment: Image-Guided SBRT vs External Beam RT for Localized Spine Metastasis